Endocrine Abstracts

The GH response to standard provocative tests is significantly lower in adult patients with Prader–Willi syndrome (PWS) than obese controls with similar body mass index (BMI). Nevertheless, BMI is an inadequate measure of body composition in PWS, because PWS harbour a higher fat mass than simple obesity, under the same degree of weight excess. This study evaluated either the GH response to combined GHRH+arginine administration and the fat body mass, by dual energy X-ray a...

Introduction: Hypothalamic–pituitary anomalies are well proven in Prader–Willi syndrome (PWS). In this context, it has been previously reported that central adrenal insufficiency (CAI) may be part of the PWS phenotype. However, the diagnostics of CAI is critical and debated, due to the lack of fully reliable tests. Several studies have looked at the clinical usefulness of the low dose (1 μg) short Synacthen test (LDSST) compared to the conventional dose (250 &#9...

Mild hypothyroidism is a heterogeneous and frequent disorder in the general population that is due to autoimmune disease in most of the cases. TSH resistance is considered a rare genetic disease due to germline loss-of-function TSHR mutations. However, TSHR mutations have been mainly searched in patients with large TSH elevations and their actual prevalence among patients with mild TSH elevations (as those found in mild hypothyroidism) is so far unknown. In this study, we eval...